The polymorphic variants DRD2, DRD3, and DRD4 are associated with early efficacy and safety of antipsychotics in adolescents with an acute psychotic episode

The prospective observational study included 101 adolescents diagnosed with acute polymorphic psychotic disorder at the time of admission. Patients were followed up for 14 days. All patients received an antipsychotic as their main therapy. following scales used to assess efficacy and safety therapy on day 14: CGAS, PANSS, CGI-S, CGI-I, UKU SERS, SAS, BARS. determination variants DRD2 (rs1800497, C>T), DRD3 (rs6280, (rs324026, DRD4 (rs1800955, C>T) genes was performed by real-time polymerase chain reaction (PCR).